lupus nephritisn. Glomerulonephritis (a kidney disease affecting the capillaries)
that occurs with systemic lupus erythematosus and is characterized by hematuria (the presence of blood in the urine) progressing
to renal failure.
Stedman's Medical Dictionary
Some studies have shown that pediatric lupus is more severe and causes more renal damage than adult-onset
lupus, but no randomized, controlled treatment trials have been reported in children with systemic lupus erythematosus (SLE).Lupus
nephritis (LN) in adolescents responds similarly to mycophenolate mofetil (MMF) and IV cyclophosphamide, according to data
reported at the American College of Rheumatology (ACR).
Systemic lupus erythematosus (SLE) is a chronic autoimmune vasculitis (inflammation of a blood
vessel) that affects 1.5 million people in the United States, with approximately 160,000 new cases each year. The
clinical manifestations of this disease range from mild skin involvement to severe multi-organ involvement, including kidney
and central nervous system disease.
Half of those with SLE will develop lupus nephritis, and a proportion of those patients
will progress to end-stage renal disease (ESRD) despite aggressive therapy.
The incidence of end-stage renal disease (ESRD) due to lupus nephritis (LN) rose significantly
in the United States from 1995 to 2004. The incidence was significantly higher among African Americans and women.