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Lupus Nephritis

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lupus nephritis n.
Glomerulonephritis (a kidney disease affecting the capillaries) that occurs with systemic lupus erythematosus and is characterized by hematuria (the presence of blood in the urine) progressing to renal failure.

Some studies have shown that pediatric lupus is more severe and causes more renal damage than adult-onset lupus, but no randomized, controlled treatment trials have been reported in children with systemic lupus erythematosus (SLE).Lupus nephritis (LN) in adolescents responds similarly to mycophenolate mofetil (MMF) and IV cyclophosphamide, according to data reported at the American College of Rheumatology (ACR).
 
  Systemic lupus erythematosus (SLE) is a chronic autoimmune vasculitis (inflammation of a blood vessel)  that affects 1.5 million people in the United States, with approximately 160,000 new cases each year. The clinical manifestations of this disease range from mild skin involvement to severe multi-organ involvement, including kidney and central nervous system disease.
 
 Half of those with SLE will develop lupus nephritis, and a proportion of those patients will progress to end-stage renal disease (ESRD) despite aggressive therapy.

The incidence of end-stage renal disease (ESRD) due to lupus nephritis (LN) rose significantly in the United States from 1995 to 2004. The incidence was significantly higher among African Americans and women.

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